Author
, A Aro; Kardinaal, A F M; Salminen, I; Kark, J D; Riemersma, R A;
Delgado-Rodriguez, M; Gomez-Aracena, J; Huttunen, J K; Kohlmeier, L;
Martin, B C; Martin-Moreno, J M; Mazaev, V P; Ringstad, J; Thamm, M; van't
Veer, P; Kok, F J

Institution
Department of Nutrition, National Public Health Institute, Mannerheimintie
166, FIN-00300 Helsinki, Finland (A. Aro, MD, I. Salminen, MSc, J. K.
Huttunen, MD); EURAMIC Coordinating Centre, TNO Toxicology and Nutrition
Institute, Zeist, Netherlands (A. F. M. Kardinaal, PhD, P. van't Veer,
PhD); Hadassah Medical Organization and Hebrew University, Jerusalem,
Israel (J. D. Kark, MD); Cardiovascular Research Unit, University of
Edinburgh, UK (R. A. Riemersma, PhD); University of Granada, Spain (M.
Delgado-Rodriguez, MD); University of Malaga, Spain (J. Gomez-Aracena, MD);
Federal Health Office, Berlin, Germany (L. Kohlmeier, PhD, M. Thamm);
University of Zurich, Switzerland (B. C. Martin, MD); School of Public
Health, Madrid, Spain (J. M. Martin-Moreno, MD); Research Centre for
Preventive Medicine, Moscow, Russia (V. P. Mazaev, MD); Ostfold Central
Hospital, Fredrikstad, Norway (J. Ringstad, MD); Agricultural University,
Wageningen, Netherlands (F. J. Kok, PhD).
Correspondence: Dr Antti Aro.

Title
Adipose tissue isomeric trans fatty acids and risk of myocardial infarction
in nine countries: the EURAMIC study.[Article]

Source
Lancet. 345(8945):273-278, February 4, 1995.

Local Message
Held at Gerstein, U of Toronto

Abstract
Dietary isomeric trans fatty acids-mainly produced by hydrogenation of
oils-are suspected of increasing the risk of coronary heart disease.
Dietary trans fatty acid intake is reflected in the fatty acid composition
of adipose tissue. In an international multicentre study in eight European
countries and Israel (EURAMIC), adipose tissue aspiration samples were
obtained from 671 men with acute myocardial infarction (AMI), aged 70 years
or less, and 717 men without a history of AMI (controls). The proportion of
fatty acids, including isomeric trans monoenoic fatty acids with 18 carbon
atoms (C18:1), was determined by gas chromatography.

Although there were considerable differences between countries in mean (SD)
proportion of adipose tissue C18:1 trans fatty acids, there was no overall
difference between cases (1.61 (0.92)%) and the controls (1.57 (0.86)%).
The risk of AMI did not differ significantly from 1.0 over quartiles of
adipose C18:1 trans fatty acids: the multivariate odds ratio was 0.97 (95%
CI 0.56-1.67) for the highest versus lowest quartile. After exclusion of
subjects from Spanish centres because they had far lower proportions of
adipose trans fatty acids than subjects from other countries, there was a
tendency to increased risk of AMI in the upper quartiles of C18:1 trans;
however, the trend was not statistically significant.

Our results reflect considerable differences between countries in dietary
intake of trans fatty acids but do not suggest a major overall effect of
C18:1 trans fatty acids on risk of AMI. We cannot exclude the possibility
that trans fatty acids have a significant impact on risk of AMI in
populations with high intake.

Copyright. (C) The Lancet Ltd, 1995.

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