====    POSTDOCTORAL RESEARCH POSITIONS   =====
 
The Queensland Institute of Medical Research, Australia
 
Three vacancies exist from January 1996 for suitably qualified postdoctoral
researchers in the areas of malaria immunology, molecular biology and cell
biology to work on projects within the Malaria Laboratories of The Queensland
Institute of Medical Research.
 
Projects currently include
I.      an investigation of the cellular immunity of P. falciparum and P.
        vivax, particularly the role of cryptic epitopes in potential vaccine
        candidates
 
II.     development of murine models to study the nature of immunity to
        malaria.
 
III.    Phase I and Phase II testing of malaria vaccine candidates.  This work
        includes studies on the human T and  B cell response to vaccine
        candidates, development of in-vitro correlates of protection and
        investigation of human immune responses to experimental infections in
        humans
 
IV.     Investigation of the selection pressures required to maintain the high
        polymorphism in many malaria antigens found in field isolates
 
V.      Molecular epidemiology of malaria: measurement of transmission rates,
        genetic recombination and association of parasite types with disease,
        especially in relatively low endemic regions.
 
VI.     Investigation of the function of defined malaria antigens,
        particularly proteins in the rhoptry organelles of merozoites.  Work
        will involve subcellular localisation of antigens and attempts to
        modify the expression of these antigens through the use of anti-sense
        DNA and or transfection experiments.
 
 
Applicants for the immunology position should have a background in molecular
and cellular aspects of immunity. Experience in protein chemistry, the use of
anti-sense DNA or transfection systems would be an advantage.  For the
cellular biology position, general experience in subcellular localisation at
the light and electron microscopy level would be an advantage, and experience
with using confocal microscopy would be particularly valuable.  Some
experience in protein chemistry, metabolic labelling of proteins
immunoprecipitation and western blotting would also be advantageous.  For all
three positions, prior experience working with  malaria of other parasites is
not required, but would be useful.
 
For more information contact Prof Allan Saul ([log in to unmask]) or Prof
Michael Good ([log in to unmask]). Phone 07 3362 0400, FAX 07 3362 0104.
 
Formal applications (enclosing a C.V. and names and addresses of three
referees)  should be addressed to:
The Secretary,
The Queensland Institute of Medical Research,
P.O. Royal Brisbane Hospital,
Qld 4029, Australia,
 
 
by the 30th October 1995.