==== POSTDOCTORAL RESEARCH POSITIONS ===== The Queensland Institute of Medical Research, Australia Three vacancies exist from January 1996 for suitably qualified postdoctoral researchers in the areas of malaria immunology, molecular biology and cell biology to work on projects within the Malaria Laboratories of The Queensland Institute of Medical Research. Projects currently include I. an investigation of the cellular immunity of P. falciparum and P. vivax, particularly the role of cryptic epitopes in potential vaccine candidates II. development of murine models to study the nature of immunity to malaria. III. Phase I and Phase II testing of malaria vaccine candidates. This work includes studies on the human T and B cell response to vaccine candidates, development of in-vitro correlates of protection and investigation of human immune responses to experimental infections in humans IV. Investigation of the selection pressures required to maintain the high polymorphism in many malaria antigens found in field isolates V. Molecular epidemiology of malaria: measurement of transmission rates, genetic recombination and association of parasite types with disease, especially in relatively low endemic regions. VI. Investigation of the function of defined malaria antigens, particularly proteins in the rhoptry organelles of merozoites. Work will involve subcellular localisation of antigens and attempts to modify the expression of these antigens through the use of anti-sense DNA and or transfection experiments. Applicants for the immunology position should have a background in molecular and cellular aspects of immunity. Experience in protein chemistry, the use of anti-sense DNA or transfection systems would be an advantage. For the cellular biology position, general experience in subcellular localisation at the light and electron microscopy level would be an advantage, and experience with using confocal microscopy would be particularly valuable. Some experience in protein chemistry, metabolic labelling of proteins immunoprecipitation and western blotting would also be advantageous. For all three positions, prior experience working with malaria of other parasites is not required, but would be useful. For more information contact Prof Allan Saul ([log in to unmask]) or Prof Michael Good ([log in to unmask]). Phone 07 3362 0400, FAX 07 3362 0104. Formal applications (enclosing a C.V. and names and addresses of three referees) should be addressed to: The Secretary, The Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Qld 4029, Australia, by the 30th October 1995.