My favorite method for sniffing out a bogus Twain search is to put the phrase in Google Books. This one got more than 800 hits - that settles it! A real quote. But wait - let's limit to books published before 1920. Than the count drops to zero. Nice try and thanks for playing the game, but not a Twain Quote. As wonderful as the Internet is at giving us access to all kinds of information, it has also given us stunning access to gibble gabble. 
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From: Mark Twain Forum [[log in to unmask]] on behalf of Shapiro, Fred [[log in to unmask]]
Sent: Saturday, January 28, 2012 7:11 PM
To: [log in to unmask]
Subject: Re: quotation verification

Like most quotes attributed to Twain, this one seems too banal and too mode=
rn in its diction to be authentic.=0A=
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Fred Shapiro=0A=
Editor=0A=
YALE BOOK OF QUOTATIONS (Yale University Press)=0A=
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From: Mark Twain Forum [[log in to unmask]] on behalf of JULES AUSTIN HOJNOWS=
KI [[log in to unmask]]=0A=
Sent: Friday, January 27, 2012 11:27 PM=0A=
To: [log in to unmask]
Subject: Re: quotation verification=0A=
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I looked in the "L's" in=0A=
http://www.twainquotes.com/L.html=0A=
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and did not see anything.=0A=
I googled the quote,  and got this:=0A=
http://www.google.com/search?q=3D3D%22The+worst+loneliness+is+not+to+be+com=
fo=3D=0A=
rtable+with+yourself.%22&ie=3D3Dutf-8&oe=3D3Dutf-8&aq=3D3Dt&rls=3D3Dorg.moz=
illa:en-=3D=0A=
US:official&client=3D3Dfirefox-a=0A=
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the one site said:=0A=
http://answers.yahoo.com/question/index?qid=3D3D20081103184240AAtKGHc=0A=
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"the worst loneliness is not to be comfortable with yourself"- Mark Twain?=
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what does this quote mean? can u explain please=0A=
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    * 3 years ago=0A=
    * Report Abuse=0A=
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strooxstroox by strooxst...=0A=
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Member since:=0A=
    October 30, 2008=0A=
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Best Answer - Chosen by Asker=0A=
I can't say for sure, I've never heard this quote before, but I would imagi=
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ne it has to do with developmental psychology, or at least the concept of a=
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utonomy.=0A=
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Basically, think of the common phrase, "GURL, no one can love you like you =
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can!" It's an encouragement to not measure your self worth based on how oth=
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er people view you. It's saying that as long as you're happy with who you a=
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re, then no one can bring you down.=0A=
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In this case, however, it is saying that even if you have all the friends i=
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n the world, you can still feel lonely and separated from the world if you =
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are are putting on a false face or just acting to gain other people's appro=
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val.=0A=
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Asker's Rating:=0A=
    5 out of 5=0A=
Asker's Comment:=0A=
    good explanation=0A=
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So I think it is not a Twain saying, sorry!=0A=
Jules=0A=
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-----Original Message-----=0A=
From: Mark Twain Forum [mailto:[log in to unmask]] On Behalf Of Sara Bader=0A=
Sent: Friday, January 27, 2012 9:04 PM=0A=
To: [log in to unmask]
Subject: quotation verification=0A=
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Hi,=0A=
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I'm trying to verify a quotation that is widely attributed to Mark Twain bu=
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t I have yet to find a primary source for it-=0A=
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"The worst loneliness is not to be comfortable with yourself."=0A=
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Does anyone know if Twain said or wrote this?=0A=
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Many thanks in advance,=0A=
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Sara Bader=0A=